Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
Abstract Background O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling.OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe.OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch.Here, we investigate the respective cont